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Cerebellar Gray Matter Volume in Tinnitus.

Lilian M Mennink1,2,3, Elouise A Koops2,3, Dave R M Langers4

  • 1Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Frontiers in Neuroscience
|May 16, 2022
PubMed
Summary

Tinnitus is not linked to cerebellar gray matter volume in healthy individuals. Previous studies suggested a link after cerebellopontine angle tumor removal, but this research found no such association in healthy participants.

Keywords:
cerebellumflocculusgray matter volumehearing lossparaflocculustinnitus

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Auditory Science

Background:

  • Tinnitus, the perception of sound without an external source, is a complex auditory disorder.
  • The cerebellum, particularly the flocculus (FL) and paraflocculus (PFL), has been implicated in tinnitus pathophysiology.
  • Prior research indicated a correlation between (P)FL-complex volume and tinnitus severity in patients post-cerebellopontine angle (CPA) tumor removal.

Purpose of the Study:

  • To investigate the relationship between tinnitus and gray matter volume (GMV) in the (P)FL-complex and other cerebellar structures in healthy individuals.
  • To determine if GMV differences in the cerebellum correlate with tinnitus presence or severity in a non-clinical population.

Main Methods:

  • Utilized the SUIT (Spatial Identification of the Human Cerebellum) toolbox for detailed analysis of cerebellar imaging data.
  • Compared GMV of all cerebellar lobules and nuclei between participants with and without tinnitus.
  • Assessed the correlation between tinnitus severity (Tinnitus Handicap Inventory) and GMV of the (P)FL-complex, tonsils, and total cerebellar cortex.

Main Results:

  • No significant differences in GMV were found in any cerebellar lobules or nuclei between tinnitus and non-tinnitus groups.
  • No correlation was observed between tinnitus severity and the GMV of the (P)FL-complex, tonsils, or total cerebellar cortex.
  • These findings contrast with previous studies on patients with CPA tumor removal.

Conclusions:

  • In otherwise healthy individuals, cerebellar GMV, including the (P)FL-complex, is not associated with the presence or severity of tinnitus.
  • The observed relationship between the (P)FL-complex and tinnitus may be specific to conditions involving cerebellar damage, such as post-CPA tumor removal.
  • Further research is needed to elucidate the precise role of the (P)FL-complex in tinnitus, potentially employing more sensitive methods to detect subtle GMV variations.