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Related Experiment Video

Updated: Sep 23, 2025

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

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Fabricating self-powered microfluidic devices via 3D printing for manipulating fluid flow.

Sung Oh Woo1, Myungkeun Oh2, Yongki Choi1,2,3

  • 1Department of Physics, North Dakota State University, Fargo, ND 58108, USA.

STAR Protocols
|May 16, 2022
PubMed
Summary

3D printing enables novel self-powered microfluidic devices for controlling blood flow and plasma separation. Researchers developed both polydimethylsiloxane (PDMS) and non-PDMS devices using 3D-printed molds and components.

Keywords:
BiophysicsBiotechnology and bioengineering

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Area of Science:

  • Biotechnology
  • Materials Science
  • Engineering

Background:

  • 3D printing offers high resolution for complex microscale fabrication.
  • Microfluidic devices are crucial for precise fluid handling in biological applications.
  • Self-powered systems eliminate external power sources, simplifying microfluidic device operation.

Purpose of the Study:

  • To present two distinct 3D printing-based methods for fabricating self-powered microfluidic devices.
  • To demonstrate the application of these devices in controlling blood flow and separating blood plasma.
  • To highlight the versatility of 3D printing in creating microfluidic solutions.

Main Methods:

  • Fabrication of polydimethylsiloxane (PDMS)-based microfluidic devices using 3D-printed molds for vacuum pockets.
  • Development of non-PDMS microfluidic devices powered by removable vacuum batteries made from 3D-printed materials.
  • Utilizing microfluidic devices for precise control of blood flow and efficient blood plasma separation.

Main Results:

  • Successful fabrication of self-powered microfluidic devices using two distinct 3D printing approaches.
  • Demonstrated capability of the devices to effectively control blood flow dynamics.
  • Achieved efficient separation of blood plasma using the developed microfluidic systems.

Conclusions:

  • 3D printing is a powerful tool for creating advanced, self-powered microfluidic devices.
  • These devices offer practical solutions for blood handling applications, including flow control and plasma separation.
  • The described methods provide accessible routes for fabricating microfluidic devices for research and diagnostics.