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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Symptomatic Myocarditis Post COVID-19 Vaccination

Palak Patel1, Dhaval Desai2,3, Nagapratap Ganta1

  • 1Internal Medicine, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.

Cureus
|May 16, 2022
PubMed

Insights

Rarely, coronavirus disease 2019 (COVID-19) vaccines cause major adverse events. Myocarditis and pericarditis are increasingly reported in young people after mRNA COVID-19 vaccines, highlighting the need for early diagnosis and treatment.

Area of Science:

  • Cardiology
  • Vaccinology
  • Public Health

Background:

  • The coronavirus disease 2019 (COVID-19) pandemic necessitated rapid vaccine development.
  • While generally safe, rare adverse events following immunization require ongoing surveillance.

Observation:

  • An increase in myocarditis and pericarditis cases has been reported to the Vaccine Adverse Event Reporting System (VAERS).
  • These cases predominantly affect young individuals after receiving messenger RNA (mRNA) COVID-19 vaccines, particularly the second dose.

Findings:

  • This case series details myopericarditis following mRNA (Moderna) vaccination and myocarditis post vector-based (Johnson & Johnson) COVID-19 vaccination.
  • The findings underscore a potential association between COVID-19 vaccines and inflammatory cardiac conditions.

Implications:

  • Early diagnosis and prompt treatment are crucial for managing vaccine-related myocarditis and pericarditis.
  • Understanding these adverse events aids in optimizing vaccine safety monitoring and patient care strategies.

Keywords:
covid-19johnson & johnsonmodernamyocarditisvaccinevaccine adverse event reporting system

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