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Granular Parakeratosis With Spontaneous Resolution: A Case Report.
Ghada Alhayaza1, Meshal Alessa2, Ohoud Alsaedi1
1Dermatology and Dermatologic Surgery, Prince Sultan Military Medical City, Riyadh, SAU.
Cureus
|May 16, 2022
Summary
Granular parakeratosis (GP) is a rare skin condition presenting as scaly papules. This case highlights a self-resolving instance of GP, emphasizing its variable natural course.
Area of Science:
- Dermatology
- Histopathology
Background:
- Granular parakeratosis (GP) is a rare, idiopathic, self-limiting skin disorder.
- It presents as erythematous to brown hyperkeratotic or scaly papules, often coalescing into plaques, typically in intertriginous areas.
Observation:
- A 47-year-old female presented with asymptomatic, linear, brown, scaly papules in the infra-abdominal fold.
- The patient reported a three-year history of applying almond oil and Sudocrem Antiseptic Healing Cream®.
- Histopathology confirmed GP by showing retained basophilic keratohyalin granules in the stratum corneum.
Findings:
- The patient's infra-abdominal granular parakeratosis resolved completely within one month with conservative management (emollients).
- This case illustrates the potential for spontaneous resolution in GP, despite varied clinical presentations and treatment outcomes.
Implications:
- GP is a rare disorder with variable clinical presentations and natural history, ranging from spontaneous resolution to chronic conditions.
- The lack of consistently effective treatments underscores the need for further research into standardized management protocols for granular parakeratosis.
