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Intestinal Perforation as a Paradoxical Reaction to Tuberculosis

Mohamad B Alebaji1, Abdelrahman I Omara2

  • 1Pediatric Medicine, Tawam Hospital, Abu Dhabi, ARE.

Cureus
|May 16, 2022
PubMed

Insights

Paradoxical reactions (PR) to tuberculosis (TB) treatment can cause worsening symptoms. This case highlights a rare gastrointestinal PR, intestinal perforation, occurring during TB therapy.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Pulmonology

Background:

  • Paradoxical reactions (PR) are a known complication of tuberculosis (TB) treatment, involving initial improvement followed by clinical or radiological worsening.
  • Gastrointestinal involvement in PR is uncommon, and intestinal perforation is a rare but severe complication of intestinal TB.

Observation:

  • A 29-year-old female presented with fever, abdominal pain, and watery diarrhea, diagnosed with intestinal TB.
  • During anti-TB treatment, she developed symptoms indicative of intestinal perforation.

Findings:

  • The patient experienced intestinal perforation as a paradoxical reaction to her anti-TB therapy.
  • This case underscores the potential for severe gastrointestinal complications during TB treatment.

Implications:

  • Highlights the importance of recognizing and managing rare gastrointestinal paradoxical reactions in TB patients.
  • Suggests vigilance for intestinal perforation as a potential complication, even after initiating treatment for intestinal TB.
  • Emphasizes the need for prompt surgical and medical management for intestinal perforation in the context of TB treatment.
Keywords:
arab countriesintestinal perforationparadoxical reactiontuberculosisuae

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