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Trachea01:22

Trachea

2.8K
The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
2.8K
Anatomy of Respiratory System II: Lower Respiratory Tract01:31

Anatomy of Respiratory System II: Lower Respiratory Tract

1.7K
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
1.7K
The Bronchial Tree01:23

The Bronchial Tree

3.8K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
3.8K
The Contractile Ring02:15

The Contractile Ring

6.5K
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
6.5K
Tracheostomy Decannulation01:21

Tracheostomy Decannulation

425
Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
425
Tracheostomy: Procedure and Tubes01:28

Tracheostomy: Procedure and Tubes

1.4K
A tracheostomy is a surgical procedure that creates an artificial opening into the trachea, typically at the second or third cartilaginous ring level. This opening allows the insertion of a tracheostomy tube, which can replace an endotracheal tube, provide mechanical ventilation, bypass an upper airway obstruction, or remove accumulated tracheobronchial secretions.
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
1.4K

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Related Experiment Video

Updated: Sep 23, 2025

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
09:57

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

Published on: April 1, 2019

7.4K

Tracheal Ring Formation.

Dagmar Iber1,2, Malte Mederacke1,2

  • 1Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

Frontiers in Cell and Developmental Biology
|May 16, 2022
PubMed
Summary
This summary is machine-generated.

The trachea

Keywords:
SOX9Turing patterncartilage ringschemotaxisdifferential adhesiondifferential growthsymmetry breaktrachea

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Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
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Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease

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Related Experiment Videos

Last Updated: Sep 23, 2025

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Area of Science:

  • Developmental biology
  • Molecular biology
  • Tissue engineering

Background:

  • The trachea's structure, with cartilage rings and smooth muscle, supports its dual function in air and food passage.
  • The dorsal-ventral axis symmetry break in the trachea is understood, but the mechanism behind cartilage ring formation is unclear.

Purpose of the Study:

  • To review the molecular mechanisms regulating periodic SOX9 expression in trachea development.
  • To discuss potential self-organization principles underlying cartilage ring patterning.

Main Methods:

  • Literature review of molecular regulatory interactions.
  • Analysis of gene expression patterns, particularly SOX9.
  • Discussion of developmental patterning mechanisms.

Main Results:

  • Elucidation of molecular interactions involved in SOX9 expression.
  • Identification of potential self-organization principles for cartilage ring formation.
  • Understanding the genetic basis for trachea structural organization.

Conclusions:

  • The molecular basis for SOX9 periodicity and cartilage ring formation is complex.
  • Self-organization principles are crucial for understanding trachea development.
  • Insights can inform biomedical interventions and tissue engineering strategies for tracheal defects.