Related Experiment Video
Updated: Sep 23, 2025
Noninvasive Electrocardiography in the Perinatal Mouse
Published on: June 12, 2020
Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective
S C Chivers1,2, T Vasavan1, M Nandi3
1Department of Women and Children's Health, King's College London, London, UK.
Objective:
Establish whether the reliable measurement of cardiac time intervals of the fetal ECG can be automated and to address whether this approach could be used to investigate large datasets.
Design:
Retrospective observational study.
Setting:
Teaching hospitals in London UK, Nottingham UK and New York USA.
Participants:
Singleton pregnancies with no known fetal abnormality.
Methods:
Archived fetal ECG's performed using the MonicaAN24 monitor. A single ECG (PQRST) complex was generated from 5000 signal-averaged beats and electrical cardiac time intervals measured in an automated way and manually.
Main Outcome Measure:
Validation of a newly developed algorithm to measure the cardiac time intervals of the fetal ECG.
Results:
188/236 (79.7%) subjects with fECGs of suitable signal:noise ratio were included for analysis comparing manual with automated measurement. PR interval was measured in 173/188 (92%), QRS complex in 170/188 (90%) and QT interval in 123/188 (65.4%). PR interval was 107.6 (12.07) ms [mean(SD)] manual vs 109.11 (14.7) ms algorithm. QRS duration was 54.72(6.35) ms manual vs 58.34(5.73) ms algorithm. QT-interval was 268.93 (21.59) ms manual vs 261.63 (36.16) ms algorithm. QTc was 407.5(32.71) ms manual vs 396.4 (54.78) ms algorithm. The QRS-duration increased with gestational age in both manual and algorithm measurements.
Conclusion:
Accurate measurement of fetal ECG cardiac time intervals can be automated with potential application to interpretation of larger datasets.
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