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Improved Clinical Workflow for Whole-Body Patlak Parametric Imaging Using Two Short Dynamic Acquisitions
Hui Wang1, Ying Miao2, Wenjing Yu1
1Department of Nuclear Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Frontiers in Oncology
|May 16, 2022
Summary
Shortening dynamic 18F-FDG PET scans to two intervals (0-6 min and 60-75 min post-injection) is feasible for generating multiparametric images. This approach maintains quantitative accuracy and can improve patient throughput for parametric analysis.
Area of Science:
- Nuclear Medicine
- Radiochemistry
- Medical Imaging
Background:
- Multiparametric positron emission tomography (PET) studies, particularly those using 18F-FDG, provide valuable quantitative insights into tissue metabolism and disease.
- Traditional dynamic PET protocols involve extended scan times, potentially limiting patient throughput and increasing discomfort.
- Optimizing acquisition protocols to reduce scan duration while preserving quantitative accuracy is crucial for clinical implementation.
Purpose of the Study:
- To evaluate the feasibility of reducing acquisition times for multiparametric 18F-FDG PET studies by utilizing two short dynamic scan intervals.
- To assess the impact of shortened dynamic PET acquisition on the quantitative performance of Patlak parametric imaging.
- To determine if reduced scan times maintain the accuracy of quantitative metrics derived from MR_FDG and DV_FDG images.
Main Methods:
- Twenty-one patients underwent standard 75-minute whole-body dynamic 18F-FDG PET/CT scans.
- Two sets of Patlak parametric images were generated: standard (0-75 min) and short dynamic (0-6 min + 60-75 min post-injection).
- Quantitative values (maximum, mean, peak) were compared between standard and short dynamic acquisitions using Passing-Bablok regression and Bland-Altman analysis.
Main Results:
- High correlations were observed between standard and short dynamic MR_FDG and DV_FDG images for both normal organs and lesions (Spearman's rho 0.962–0.982, p < 0.0001).
- Quantitative metrics (maximum, mean, peak values) showed agreement between standard and short dynamic acquisitions.
- Bland-Altman analysis indicated minimal mean bias for MR_FDG metrics and acceptable bias for DV_FDG metrics in both normal organs and lesions.
Conclusions:
- Utilizing two short dynamic scans (0-6 min and 60-75 min post-injection) is feasible for generating accurate Patlak multiparametric images.
- This shortened acquisition protocol preserves quantitative performance, demonstrating its potential for clinical application.
- The proposed method can enhance patient throughput in parametric PET imaging analyses.
