Related Experiment Video
Updated: Sep 23, 2025
08:11
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
8.5K
Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential
Briana E Heinly1, Christa N Grant1,2
1Penn State College of Medicine, Hershey, PA, United States.
Frontiers in Oncology
|May 16, 2022
Summary
Cell adhesion molecules (CAMs) play a role in neuroblastoma metastasis and patient prognosis. Targeting CAMs offers potential for novel neuroblastoma therapies, though further research is needed.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Neuroblastoma is a significant cause of childhood cancer mortality.
- Cell adhesion molecules (CAMs) are implicated in cancer metastasis, including detachment, migration, and invasion.
- CAM expression in neuroblastoma correlates with patient prognosis.
Purpose of the Study:
- To review the current literature on the role of CAMs in neuroblastoma.
- To explore the potential of CAMs as therapeutic targets for neuroblastoma.
Main Methods:
- Literature review of scientific publications on neuroblastoma and CAMs.
Main Results:
- Expression of various CAMs in neuroblastoma tumors is linked to clinical outcomes.
- CAMs are involved in the metastatic processes of neuroblastoma cells.
Conclusions:
- CAMs represent promising therapeutic targets for neuroblastoma.
- Further scientific exploration is required to translate CAM-based therapies into clinical practice for neuroblastoma treatment.
Related Concept Videos
01:31Immunoglobulin-like Cell Adhesion Molecules
3.4K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.4K
01:20Cell Adhesion Molecules - Types and Functions
7.6K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved...
CAM Families
The Integrin family of proteins is primarily involved...
7.6K
02:38Mitogens and the Cell Cycle
7.0K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.0K
01:00Enzyme-linked Receptors
80.2K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
80.2K
01:19Cadherins in Tissue Organization
3.2K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.2K
01:14Cell Adhesion in Plants
2.9K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
2.9K