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Assessment of Social Interaction Behaviors
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GSK-3β Inhibition in Birds Affects Social Behavior and Increases Motor Activity.

Stan Moaraf1, Ido Rippin2, Joseph Terkel1

  • 1School of Zoology, Tel-Aviv University, Tel-Aviv, Israel.

Frontiers in Physiology
|May 16, 2022
PubMed
Summary

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Inhibition of glycogen synthase kinase-3 beta (GSK-3β) in zebra finches altered social recognition, increased anxiety-like behavior, and enhanced motor activity and motivation. This research provides insights into GSK-3β

Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Molecular Biology

Background:

  • Glycogen synthase kinase-3 (GSK-3) is a key protein kinase regulating cellular processes, cognition, and behavior.
  • GSK-3 alpha and beta isozymes are conserved in vertebrates, but the alpha gene is absent in birds, allowing for independent study of GSK-3 beta.
  • GSK-3 is implicated in mood disorders, cognitive functions, and neuronal health.

Purpose of the Study:

  • To investigate the role of GSK-3 beta in social behavior, motivation, and motor activity in zebra finches (Taeniopygia guttata).
  • To understand the independent function of GSK-3 beta in a model organism lacking GSK-3 alpha.

Main Methods:

  • Selective inhibition of GSK-3 beta in adult male zebra finches.
  • Utilized laboratory-designed behavioral assays to assess social recognition, anxiety, decision-making, motor activity, and motivation.
Keywords:
GSK-3birdscognitionmotor activitysociabilityzebra finches

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  • Compared behavioral responses of GSK-3 beta inhibited birds with control groups.

    • Main Results:

    • GSK-3 beta inhibition impaired social recognition, with birds approaching strangers instead of familiar individuals.
    • Inhibited birds exhibited increased time in central cage areas, suggesting anxiety.
    • Decision-making speed was reduced in treated birds as the experiment progressed.
    • Motor activity significantly increased in GSK-3 beta inhibited birds, indicative of hyperactivity.
    • Inhibited birds showed heightened motivation, crossing barriers faster to rejoin flocks.

    Conclusions:

    • GSK-3 beta plays a significant role in modulating social behavior, anxiety levels, decision-making, motor control, and motivation in zebra finches.
    • Targeting GSK-3 beta may offer therapeutic potential for cognitive and behavioral disorders.
    • Further research is warranted to explore GSK-3's diverse functions in normal behavior and disease states.