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The complex search for the cause of gastroschisis
Amanda Brasil de Freitas1,2, Rossana Pulcineli Vieira Francisco1, Mara Sandra Hoshida3
1Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Sao Paulo, Brazil.
Background:
To reveal the complex etiology of gastroschisis through two independent cases.
Cases:
Case 1 involves gastroschisis recurrence in a consanguineous marriage, and Case 2 concerns a fetus with gastroschisis whose mother had undergone gastroplasty. Methylation array was carried out in both cases (two fetuses with gastroschisis, their two mothers, one father from the consanguineous marriage), and in 16 controls (fetuses and their respective mothers).
Conclusion:
The two cases presented different noninherited methylation profiles.
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