[Chinese expert consensus on diagnosis and treatment of traumatic multiple organ dysfunction syndrome]

Multiple organ dysfunction syndrome (MODS) is the main cause of high mortality in late stage of patients following major trauma. On the basis of literature retrieval and analysis, combined with evidence-based medicine and clinical trial reports together with expert experiences in clinical practice, we compiled this expert consensus, which focused on the pathophysiological mechanism, early prediction, diagnosis, treatment, and rehabilitation of traumatic MODS, in order to help clinicians understand the basic pathogenesis and standardize the clinical management. The pathogenic mechanisms of MODS after severe trauma mainly include excessive inflammatory response, immune dissonance, abnormal coagulation, and the dysregulated networks among multiple organs as well as systems. Early and accurate diagnosis, timely and appropriate organ support, and adjuvant therapy might effectively improve the poor outcomes of patients with traumatic MODS.