Relationship Between Neutrophil-Lymphocyte Ratio and Drug-Coated Balloon Restenosis in Patients With Femoropopliteal Arterial Disease

Area of Science:

• Vascular Surgery
• Interventional Cardiology
• Biomarkers in Cardiovascular Disease

Background:

• Femoropopliteal arterial disease is a common cause of peripheral artery disease.
• Drug-coated balloon (DCB) angioplasty is a treatment option, but restenosis remains a challenge.
• Identifying predictors of restenosis is crucial for improving patient outcomes.

Purpose of the Study:

• To investigate the association between neutrophil-lymphocyte ratio (NLR) and restenosis in patients undergoing DCB angioplasty for femoropopliteal arterial disease.
• To determine if NLR is an independent predictor of late restenosis.
• To establish a potential cutoff value for NLR in predicting restenosis.

Main Methods:

• Retrospective analysis of 120 patients treated with DCB angioplasty.
• Patients were categorized based on restenosis development and timing.
• Multivariate logistic regression and ROC curve analysis were used to assess NLR's predictive value.

Main Results:

• Postoperative NLR was significantly higher in the late-restenosis group compared to the no-restenosis group (3.53 vs 2.70, p=0.011).
• Postoperative NLR independently predicted late restenosis (OR 1.404, p=0.014).
• A cutoff NLR of 2.78 showed 80.8% sensitivity and 53.2% specificity for predicting late restenosis, with a higher incidence in patients with NLR ≥ 2.78 (32.3% vs 9.1%, p=0.002).

Conclusions:

• Postoperative neutrophil-lymphocyte ratio is an independent predictor of late restenosis in patients with femoropopliteal arterial disease treated with DCB angioplasty.
• NLR may serve as a valuable biomarker for risk stratification in these patients.
• Further prospective studies are warranted to confirm these findings.