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Updated: Sep 23, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
Activation and turnover of the plant immune signaling kinase BIK1: a fine balance
Márcia Gonçalves Dias1,2, Faranak Soleimani1, Jacqueline Monaghan1
1Department of Biology, Queen's University, Kingston ON K7L 3N6, Canada.
Abstract:
Mechanisms to sense and respond to pathogens have evolved in all species. The plant immune pathway is initiated by the activation of transmembrane receptor kinases that trigger phosphorylation relays resulting in cellular reprogramming. BOTRYTIS-INDUCED KINASE 1 (BIK1) is a direct substrate of multiple immune receptors in Arabidopsis thaliana and is a central regulator of plant immunity. Here, we review how BIK1 activity and protein stability are regulated by a dynamic interplay between phosphorylation and ubiquitination.
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