Related Experiment Video
Updated: Sep 23, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Cold Exposure and the Metabolism of Mice, Men, and Other Wonderful Creatures
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Abstract:
Laboratory rodents and cold-adapted animals in the wild use a significant amount of the energy derived from food intake for heat generation. Thermogenesis involving mitochondrial uncoupling in the brown adipose tissue differs quantitatively in mice, humans, and cold-adapted animals and could be an important ally to combat obesity if humans were prepared to deviate slightly from thermoneutral living conditions to activate this pathway.
Related Concept Videos
Decreased Body Temperature
Responses to Heat and Cold Stress
Homeostatic Imbalances in Body Temperature

