Synthesis of Block Copolymers by Mechanistic Transformation from Reversible Complexation Mediated Living Radical Polymerization to the Photoinduced Radical Oxidation/Addition/Deactivation Process
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Updated: Sep 23, 2025

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Cansu Aydogan1, F Simal Aykac1, Gorkem Yilmaz1
1Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey.
Abstract:
A versatile strategy for the fabrication of block copolymers by the combination of two discrete living polymerization techniques─reversible complexation mediated living radical polymerization (RCMP) and photoinduced radical oxidation addition deactivation (PROAD) processes─is reported. First, RCMP is conducted to yield poly(methyl methacrylate) with iodide end groups (PMMA-I). In the following step, PMMA-I is used as macroinitiator for living PROAD cationic polymerization of isobutyl vinyl ether. Successful formation of the block copolymers is confirmed by 1H NMR, FT-IR, GPC, and DSC investigations.
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