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The Aortic Ductus Diverticulum-Innocent Bystander or Potential Source of Thromboembolic Stroke?

Erkan Celik1, Lukas Goertz1, Christian Nelles1

  • 1From the Department of Diagnostic and Interventional Radiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne.

Journal of Computer Assisted Tomography
|May 16, 2022
PubMed

Insights

Aortic ductus diverticula (ADDs) were not significantly linked to ischemic brain alterations in a study of 218 patients. These outpouchings appear to be an innocent bystander regarding stroke pathogenesis.

Area of Science:

  • Cardiovascular Imaging
  • Neurology
  • Radiology

Background:

  • Outpouchings at the aortic isthmus, known as aortic ductus diverticula (ADDs), may pose a risk for thrombus formation due to reversed diastolic blood flow.
  • Thrombus formation in ADDs could lead to thromboembolic events, potentially affecting the brain.

Purpose of the Study:

  • To investigate the association between the presence of aortic ductus diverticula (ADDs) and the occurrence of ischemic brain alterations.
  • To determine if ADDs are a risk factor for cerebrovascular events.

Main Methods:

  • Retrospective analysis of 218 patients who underwent thoracic aorta CT angiography and brain MRI.
  • Independent review of imaging by two radiologists to identify ADDs and ischemic brain alterations.
  • Statistical analysis using univariate and bivariate logistic regression to assess the association.

Main Results:

  • Aortic ductus diverticula (ADDs) were identified in 16% (35/218) of the study population.
  • Ischemic brain alterations were observed in 57% of patients with ADDs versus 42% in the control group (P=0.1).
  • Multivariate analysis indicated that ADDs were not an independent risk factor for ischemic brain alterations (OR=1.7, P=0.225).

Conclusions:

  • The study found no significant association between aortic ductus diverticula (ADDs) and ischemic brain alterations.
  • Aortic ductus diverticula (ADDs) are likely incidental findings and not a direct cause of ischemic brain changes.
Abstract

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