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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Heart Failure Drugs: Diuretics01:22

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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Updated: Sep 23, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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HDL and Kidney Diseases.

Huanhuan Cao1, Xia Meng2

  • 1The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.

Advances in Experimental Medicine and Biology
|May 16, 2022
PubMed
Summary
This summary is machine-generated.

Kidney diseases alter lipid profiles, particularly high-density lipoprotein (HDL) cholesterol. Impaired HDL function in chronic kidney disease (CKD) may contribute to cardiovascular disease (CVD), suggesting HDL as a therapeutic target.

Keywords:
Chronic kidney diseaseHDLNephrotic syndrome

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Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Lipid Metabolism

Background:

  • Serum lipid profiles, including high-density lipoprotein (HDL), are frequently altered in patients with kidney diseases.
  • Kidney diseases, such as nephrotic syndrome and chronic kidney disease (CKD), significantly impact lipid metabolism and HDL functionality.

Purpose of the Study:

  • To investigate the alterations in HDL cholesterol and its related components in patients with nephrotic syndrome and CKD.
  • To explore the functional changes of HDL in CKD and its implications for cardiovascular disease (CVD).
  • To assess the potential of HDL as a therapeutic target for managing CVD complications in CKD patients.

Main Methods:

  • Analysis of serum lipid profiles, including HDL cholesterol and apolipoprotein A-I (ApoA-I) levels.
  • Comparison of lipid profiles and HDL cholesterol: total cholesterol ratio between kidney disease patients and healthy individuals.
  • Assessment of HDL's reverse cholesterol transport function in CKD patients.

Main Results:

  • In nephrotic syndrome, plasma HDL cholesterol and ApoA-I levels were within or below normal limits, with a decreased HDL cholesterol: total cholesterol ratio.
  • Chronic kidney disease (CKD) impairs the reverse cholesterol transport function of HDL.
  • CKD affects both the composition and function of HDL particles.

Conclusions:

  • Alterations in HDL are characteristic of kidney diseases, including nephrotic syndrome and CKD.
  • Impaired HDL function in CKD contributes to the high risk of cardiovascular disease (CVD).
  • Targeting HDL may offer a novel strategy for preventing cardiovascular complications in CKD.