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HDL and Kidney Diseases

Huanhuan Cao1, Xia Meng2

  • 1The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.

Advances in Experimental Medicine and Biology
|May 16, 2022
PubMed

Insights

Kidney diseases alter lipid profiles, particularly high-density lipoprotein (HDL) cholesterol. Impaired HDL function in chronic kidney disease (CKD) may contribute to cardiovascular disease (CVD), suggesting HDL as a therapeutic target.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Lipid Metabolism

Background:

  • Serum lipid profiles, including high-density lipoprotein (HDL), are frequently altered in patients with kidney diseases.
  • Kidney diseases, such as nephrotic syndrome and chronic kidney disease (CKD), significantly impact lipid metabolism and HDL functionality.

Purpose of the Study:

  • To investigate the alterations in HDL cholesterol and its related components in patients with nephrotic syndrome and CKD.
  • To explore the functional changes of HDL in CKD and its implications for cardiovascular disease (CVD).
  • To assess the potential of HDL as a therapeutic target for managing CVD complications in CKD patients.

Main Methods:

  • Analysis of serum lipid profiles, including HDL cholesterol and apolipoprotein A-I (ApoA-I) levels.
  • Comparison of lipid profiles and HDL cholesterol: total cholesterol ratio between kidney disease patients and healthy individuals.
  • Assessment of HDL's reverse cholesterol transport function in CKD patients.

Main Results:

  • In nephrotic syndrome, plasma HDL cholesterol and ApoA-I levels were within or below normal limits, with a decreased HDL cholesterol: total cholesterol ratio.
  • Chronic kidney disease (CKD) impairs the reverse cholesterol transport function of HDL.
  • CKD affects both the composition and function of HDL particles.

Conclusions:

  • Alterations in HDL are characteristic of kidney diseases, including nephrotic syndrome and CKD.
  • Impaired HDL function in CKD contributes to the high risk of cardiovascular disease (CVD).
  • Targeting HDL may offer a novel strategy for preventing cardiovascular complications in CKD.

Keywords:
Chronic kidney diseaseHDLNephrotic syndrome

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