Related Experiment Video

Updated: Sep 23, 2025

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

3.9K

HDL and Therapy

Ke Li1, Xianwei Xie2, Yansong Guo3,4,5,6,7

  • 1Beijing Tiantan Hospital, China National Clinical Research Center of Neurological Diseases, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, Beijing, China.

Advances in Experimental Medicine and Biology
|May 16, 2022
PubMed

Insights

High-density lipoprotein (HDL) shows cardioprotective effects and targets cardiovascular diseases. Recombinant HDL (rHDL) and apolipoprotein mimetic peptides offer promising therapeutic avenues for various conditions.

Area of Science:

  • Cardiovascular Science
  • Nanomedicine
  • Therapeutics

Background:

  • High-density lipoprotein (HDL) possesses significant antiatherosclerosis and cardioprotective properties.
  • HDL cholesterol (HDL-C) is a recognized therapeutic target for cardiovascular disease reduction.
  • Recombinant HDL (rHDL) and apolipoprotein mimetic peptides represent emerging therapeutic strategies.

Purpose of the Study:

  • To discuss the pleiotropic therapeutic effects of rHDL.
  • To review the applications of rHDL as a nanovector.
  • To examine clinical trial advances and future outlook for rHDL and mimetic peptide therapies.

Main Methods:

  • Literature review on rHDL and apolipoprotein mimetic peptides.
  • Discussion of rHDL's effects on atherogenesis, angiogenesis, platelets, and vascular and neurological diseases.
  • Analysis of clinical trial data and therapeutic potential.

Main Results:

  • rHDL exhibits pleiotropic therapeutic effects beyond its role in HDL.
  • rHDL functions as a nanovector for antiatherosclerotic, antitumor, and diagnostic applications.
  • Apolipoprotein mimetic peptides are in clinical assessment with promising therapeutic potential.

Conclusions:

  • rHDL and apolipoprotein mimetic peptides hold significant promise for treating cardiovascular diseases and other conditions.
  • Further clinical evaluation is warranted to fully realize the therapeutic potential of these agents.
  • rHDL's versatility as a nanovector expands its therapeutic and diagnostic applications.

Keywords:
Apolipoprotein A-IHigh-density lipoproteinMimetic peptidesRecombinant HDL therapy

More Related Videos

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy07:21

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy

Published on: June 27, 2025

151
The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.9K

Related Concept Videos

Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
160
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
107
Psychotherapy01:28

Psychotherapy

Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
180
Behavior Therapy01:22

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
117
Humanistic Therapy01:24

Humanistic Therapy

Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
113
Couples Therapy01:26

Couples Therapy

Couples therapy is a therapeutic approach designed to help individuals in intimate relationships address conflicts, improve communication, and foster healthier dynamics. It is appropriate for couples at various stages, including those who are dating, married, or in long-term partnerships, and aims to support partners in navigating their unique relational challenges.
Core Principles and Techniques
Couples therapy often incorporates cognitive-behavioral principles to identify and modify negative...
100