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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Checkpoint-inhibitor induced Polyserositis with Edema.
Sarah Zierold1,2, Larissa Semra Akcetin1, Eva Gresser3
1Department of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstraße 9-11, 80337, Munich, Germany.
Cancer Immunology, Immunotherapy : CII
|May 16, 2022
Summary
Immune checkpoint inhibitors (ICI) can cause rare side effects like serositis. Early identification of ICI-induced serositis is crucial for effective treatment and improved patient outcomes.
Area of Science:
- Oncology
- Immunology
Background:
- Immune checkpoint inhibitors (ICI) are widely used for various cancers.
- Rare side effects, including pericardial effusion in non-small cell lung cancer (NSCLC), are increasingly recognized.
- Limited data exists on ICI-induced serositis and edema in other cancer types.
Purpose of the Study:
- To describe cases of immune checkpoint inhibitor-induced serositis (irSerositis).
- To highlight the diagnostic and treatment challenges of irSerositis.
- To emphasize the importance of early irSerositis identification.
Main Methods:
- Case series of four patients with irSerositis.
- Patients had metastatic cervical cancer, melanoma, or NSCLC.
- Treatment involved steroids and fluid drainage (punctures).
Main Results:
- All patients experienced sudden onset irSerositis.
- Steroid treatment provided initial relief but not complete recovery.
- Three patients also developed peripheral edema, and all had other immune-related adverse events (irAEs).
Conclusions:
- ICI-induced serositis and effusions are complex and potentially underdiagnosed.
- Analyzing punctured fluid can help differentiate irSerositis from malignant effusions.
- Early identification and treatment with steroids are essential for symptom management.
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