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Updated: Sep 23, 2025
09:06
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.4K
Advances in relationship between cell senescence and atherosclerosis
Summary
Cellular senescence, a process of cell aging, drives atherosclerosis development through organelle changes and the senescence-associated secretory phenotype (SASP). Therapies targeting senescent cells and SASP offer new avenues for treating atherosclerosis.
Area of Science:
- Gerontology
- Cardiovascular Biology
- Cellular Biology
Background:
- Cellular senescence contributes to age-related diseases by impairing cell function.
- Atherosclerosis is an inflammatory cardiovascular disease linked to aging.
- Understanding senescence's role in atherosclerosis is crucial for developing effective treatments.
Purpose of the Study:
- To review the impact of cellular senescence on atherosclerosis development.
- To examine physiopathological changes, including organelle alterations and SASP.
- To explore therapeutic strategies targeting senescent cells and SASP.
Main Methods:
- Literature review of cellular senescence and atherosclerosis.
- Analysis of physiopathological mechanisms linking senescence to atherosclerosis.
- Evaluation of therapeutic approaches for senescent cell clearance and SASP modulation.
Main Results:
- Cellular senescence exacerbates atherosclerosis through organelle dysfunction.
- Increased senescence-associated secretory phenotype (SASP) promotes chronic inflammation in atherosclerosis.
- Senescent cell accumulation is a key driver of atherosclerotic plaque development.
Conclusions:
- Cellular senescence plays a significant role in the pathogenesis of atherosclerosis.
- Targeting senescent cells and their SASP presents a promising therapeutic strategy for atherosclerosis.
- Further research into senolytics and SASP inhibitors could revolutionize cardiovascular disease treatment.
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