Formal C-H/C-I Metathesis: Site-Selective C-H Iodination of Anilines Using Aryl Iodides
Ning Wang1,2, Zhuomin Chi2, Xinchao Wang2
1College of Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350002, China.
Abstract:
Functional group metathesis has the potential to render mild reaction conditions for C-H functionalization. Protocols for the meta- and ortho-C-H iodination of aniline derivatives via formal C(sp2)-H/C(sp2)-I metathesis using 2-nitrophenyl iodides as mild iodinating reagents are reported herein. These protocols led to the production of a range of valuable iodinated aniline derivatives. These results demonstrate the potential of developing novel site-selective C-H activation reactions with electron-rich compounds, since mild reagents can often been utilized in functional group metathesis reactions.
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