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Related Experiment Video

Updated: Sep 23, 2025

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

Pathophysiological mechanisms of ALPPS: experimental model.

Ruifeng Wang^1,2,3, Zhen Quan^1,2, Tongsen Zheng⁴

¹NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China.

The British Journal of Surgery

|May 16, 2022

Summary

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) rapidly alters liver tumor and remnant function. Molecular imaging effectively tracks these changes, aiding understanding of the ALPPS procedure.

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Area of Science:

Hepatobiliary surgery
Surgical oncology
Medical imaging

Background:

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a two-stage surgical approach to enhance liver tumor resectability.
ALPPS aims to induce rapid hypertrophy of the future liver remnant (FLR), reducing postoperative liver failure.
The precise pathophysiological mechanisms following the initial stage of ALPPS remain incompletely understood.

Purpose of the Study:

To investigate the pathophysiological mechanisms in the FLR and liver tumor after the first stage of ALPPS.
To assess the utility of molecular and functional imaging in monitoring these changes.

Main Methods:

An ALPPS rabbit model with VX2 liver tumors was established.
Multiplexed positron emission tomography (PET) tracers, dynamic contrast-enhanced MRI (DCE-MRI), and histopathology were employed.
Serial imaging and analysis were performed to evaluate tumor and FLR dynamics.

Main Results:

Tumor volume and 18F-FDG uptake increased in the ALPPS model compared to controls.
18F-methylcholine PET accurately monitored liver regeneration dynamics between days 3 and 7.
DCE-MRI indicated peak vascular hyperpermeability in both tumor and FLR on day 7.

Conclusions:

Molecular and functional imaging provide valuable non-invasive insights into ALPPS-induced pathophysiological changes.
These imaging modalities show potential for clinical application in managing patients undergoing ALPPS.