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Published on: December 6, 2016
Association between nontraditional lipid profiles and the severity of obstructive sleep apnea: A retrospective study
Yifei Fang1, Jiao Su1, Chunling Zhao1
1Department of Respiratory and Sleep Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Insights
Nontraditional lipid indices like TG/HDL-C and TC/HDL-C are positively associated with obstructive sleep apnea (OSA) severity. These lipid profiles can help predict cardiovascular disease risk in OSA patients.
Area of Science:
- Cardiology
- Sleep Medicine
- Clinical Biochemistry
Background:
- Obstructive sleep apnea (OSA) is frequently associated with dyslipidemia and cardiovascular diseases (CVDs).
- Nontraditional lipid indices offer improved prediction of cardiovascular risk compared to traditional markers.
- The relationship between nontraditional lipid profiles and OSA severity remains incompletely understood.
Purpose of the Study:
- To investigate the association between various nontraditional lipid profiles and the severity of obstructive sleep apnea (OSA).
- To evaluate the predictive performance of lipid indices for severe OSA.
Main Methods:
- Retrospective analysis of 635 patients diagnosed with OSA via polysomnography (PSG).
- Examination of associations between severe OSA and lipid profiles: triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, total cholesterol (TC)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C), atherogenic index (AI), and lipoprotein combine index (LCI).
- Statistical analyses included restricted cubic spline and multivariate logistic regression.
Main Results:
- All assessed nontraditional lipid indices demonstrated a positive relationship with OSA severity.
- Increased levels of TG/HDL-C, TC/HDL-C, LDL-C/HDL-C, non-HDL-C, AI, and LCI were significantly associated with higher risks of severe OSA.
- Specifically, per standard deviation increment, TG/HDL-C, TC/HDL-C, LDL-C/HDL-C, non-HDL-C, AI, and LCI correlated with 88%, 50%, 42%, 40%, 50%, and 125% increased risk for severe OSA, respectively.
Conclusions:
- Nontraditional lipid indices are positively correlated with OSA severity.
- TG/HDL-C, TC/HDL-C, and AI showed superior predictive performance for severe OSA compared to other indices.
- These findings can aid in assessing cardiovascular risk and optimizing dyslipidemia management in OSA patients.
Background:
Due to the significant role of dyslipidemia, cardiovascular diseases (CVDs) are very common in obstructive sleep apnea (OSA). Nontraditional lipid indices are considered to be a better predictive index for cardiovascular risk. Nevertheless, the association between nontraditional lipid profiles and the severity of OSA is not clear.
Methods:
A retrospective study was proceeded on 635 patients. Subjects were diagnosed with OSA through polysomnography (PSG). The association between severe OSA and nontraditional lipid profiles [triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, total cholesterol (TC)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C), atherogenic index (AI), and lipoprotein combine index (LCI)] was examined by utilizing the restricted cubic spline and multivariate logistic regression analysis.
Results:
All nontraditional lipid indices had positive relationships with the severity of OSA. By multivariable adjustment, the per SD increment of the TG/HDL-C, TC/ HDL-C, LDL-C/HDL-C, non-HDL-C, AI, and LCI were significantly associated with 88%, 50%, 42%, 40%, 50%, and 125% higher risk for severe OSA respectively. Compared with the lowest tertiles, the adjusted ORs (95% CI) were 2.42 (1.57-3.75), 2.39 (1.53-3.73), 2.35 (1.52-3.64), 1.86 (1.21-2.86), 2.39 (1.53-3.73), and 2.23 (1.43-3.48) for the top tertiles of TG/HDL-C, TC/ HDL-C, LDL-C/HDL-C, non-HDL-C, AI, and LCI respectively.
Conclusion:
All nontraditional lipid indices had positive relationship with the severity of OSA. In addition, TG/HDL-C, TC/HDL-C, and AI had better performance than the other nontraditional lipid indices for predicting severe OSA. These findings could help to determine the risk of cardiovascular diseases and improve the dyslipidemia management of OSA patients.
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