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Are platelet indices promising ratios for predicting pediatric septic shock prognosis?
Insights
Platelet indices, including MPV/PLT and PDW/PLT ratios, can predict mortality in children with septic shock. Higher ratios indicate a greater risk of 28-day mortality in pediatric patients.
Area of Science:
- Pediatric critical care medicine
- Hematology
- Pediatric intensive care
Background:
- Septic shock is a leading cause of mortality in children globally.
- Early identification of prognostic markers is crucial for improving outcomes.
Purpose of the Study:
- To evaluate the prognostic significance of thrombocytopenia and platelet indices (MPV/PLT and PDW/PLT) in pediatric septic shock.
- To assess the utility of these markers for predicting 28-day mortality.
Main Methods:
- Retrospective analysis of 204 children with septic shock admitted to a pediatric intensive care unit.
- Calculation of MPV/platelet and PDW/platelet ratios using data from the first three days of hospitalization.
- Correlation of these ratios with 28-day mortality outcomes.
Main Results:
- MPV/platelet (MPV/PLT) and PDW/platelet (PDW/PLT) ratios were significantly higher in non-survivors compared to survivors (p≤0.001).
- Elevated MPV/PLT ratios at 72 hours (OR: 7.41) and PDW/PLT ratios at 72 hours (OR: 2.9) were identified as significant risk factors for mortality in multivariate analysis.
Conclusions:
- Platelet indices serve as valuable laboratory parameters in managing pediatric septic shock.
- MPV/PLT and PDW/PLT ratios demonstrate potential as reliable biomarkers for predicting 28-day mortality in children with septic shock.
Objectives:
The aim of the present study was to determine the prognostic value of thrombocytopenia, platelet indices (MPV/PLT and PDW/PLT) in children with septic shock.
Background:
Septic shock is one of the major causes of mortality among children worldwide.
Methods:
A retrospective analysis was made of children admitted to the pediatric intensive care unit between November 2010 and December 2019. Two hundred four children were included; they were diagnosed with septic shock according to the international pediatric sepsis consensus conference criteria. The MPV/platelet ratio and PDW/platelet ratios were estimated as the MPV and PDW values divided by the platelet count on the first three days of hospitalization. The clinical outcome was 28-day mortality.
Results:
MPV/PLT and PDW/PLT ratios were found to be significantly higher in the non-survivors than survivor (p≤0.001). In the multivariate logistic regression analysis, higher MPV/platelet ratios at 72h (OR: 7.41; 95% CI: 1.25-43.7; p=0.027) and PDW/platelet ratios at 72h (OR: 2.9; 95% CI: 1.13-7.50; p=0.027) were significant risk factors for mortality.
Conclusions:
Platelet indices are useful laboratory parameters in septic shock. MPV/PLT and PDW/PLT ratios can be promising reliable markers for 28-day mortality in children with septic shock (Tab. 4, Fig. 1, Ref. 29).
