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Biofiltration in elderly uremic patients.

C Grimaldi, C Ciccarelli, G Monzani

    The International Journal of Artificial Organs
    |December 1, 1986
    PubMed
    Summary
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    Biofiltration (BF) offers better dialytic tolerance for elderly patients compared to conventional hemodialysis (CH). This study found BF improved hypotension and acid-base balance without negatively impacting nutritional status or key biochemical markers.

    Area of Science:

    • Nephrology
    • Geriatric Medicine
    • Biomedical Engineering

    Background:

    • Elderly patients often experience poor tolerance to conventional hemodialysis (CH).
    • Dialytic complications can include hypotension and acid-base imbalances.
    • Biofiltration (BF) is an alternative dialysis modality.

    Purpose of the Study:

    • To compare the dialytic tolerance of elderly patients undergoing conventional hemodialysis (CH) versus biofiltration (BF).
    • To assess the impact of BF on clinical status, biochemical parameters, nutritional status, and acid-base balance in elderly patients.

    Main Methods:

    • A study involving five elderly patients comparing CH and BF treatments.
    • Treatment protocols included adjustments in duration for some patients due to interdialytic weight gain.

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  • Comprehensive assessments included clinical status, biochemical data, nutritional status, and acid-base balance (ABB) at baseline and study end.

    • Main Results:

    • Plasma levels of small molecules, potassium, and phosphate remained unchanged across all patients.
    • Patients experienced fewer or less severe hypotensive episodes with BF.
    • Good control of acid-base balance (ABB) was achieved, with no instances of metabolic alkalosis.
    • Nutritional status did not worsen in any patient.

    Conclusions:

    • Biofiltration (BF) demonstrated efficacy as a dialysis choice for elderly patients compared to conventional hemodialysis (CH).
    • BF contributed to improved patient health and better management of dialysis-related complications.
    • The findings support BF as a beneficial alternative for enhancing dialytic tolerance in geriatric populations.