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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Fast-Curing Injectable Microporous Hydrogel for In Situ Cell Encapsulation.

Seth D Edwards1, Shujie Hou1, Jason M Brown1

  • 1Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire 03824, United States.

ACS Applied Bio Materials
|May 16, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces an injectable, microporous hydrogel from gelatin and GelMA microgels. This advanced scaffold promotes cell migration, proliferation, and enhances anti-inflammatory responses for regenerative medicine.

Keywords:
anti-inflammatorygelatininjectable hydrogelsmesenchymal stem cell deliverymicroporoustissue adhesion

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Injectable hydrogels are promising for tissue regeneration and cell/drug delivery.
  • Current systems often lack microporosity, hindering cell infiltration and proliferation.
  • This limits their efficacy in regenerative medicine applications.

Purpose of the Study:

  • To develop an injectable, microporous hydrogel with enhanced properties for cell delivery.
  • To overcome limitations of existing hydrogel scaffolds regarding cell migration and proliferation.
  • To investigate the potential of this hydrogel in enhancing cell behavior for regenerative medicine.

Main Methods:

  • Fabrication of injectable microporous hydrogels from gelatin/gelatin methacryloyl (GelMA) composite microgels via water-in-oil emulsion.
  • Dual-crosslinking using UV photopolymerization and microbial transglutaminase (mTG) for rapid curing and tissue adhesion.
  • In situ cell encapsulation of human dermal fibroblasts and human mesenchymal stem cells (hMSCs).

Main Results:

  • The composite microgels exhibited improved thermal stability compared to GelMA-only microgels.
  • Dual-crosslinking enabled fast hydrogel formation, reduced photoinitiator concentration, and minimized cytotoxicity.
  • Encapsulated hMSCs and fibroblasts demonstrated rapid spreading and proliferation within the hydrogel's pore space.
  • Encapsulated cells secreted prostaglandin E2 (PGE2) and interleukin-6 (IL-6), indicating enhanced anti-inflammatory behavior.

Conclusions:

  • The developed injectable microporous hydrogel offers a promising scaffold for tissue regeneration.
  • The dual-crosslinking strategy enhances hydrogel properties and biocompatibility.
  • This formulation supports cell viability, proliferation, and functional behavior, positioning it as a valuable cell delivery vehicle for regenerative medicine.