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Related Experiment Videos

Ionized calcium/total calcium ratio during biofiltration.

D A Procaccini, A Chiaravalle, D D'Altilia

    The International Journal of Artificial Organs
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Calcium transfer during hemodialysis is complex. Biofiltration may reduce calcium transfer and cause alkalosis, potentially increasing parathyroid hormone and worsening bone disease in dialysis patients.

    Area of Science:

    • Nephrology
    • Renal Physiology
    • Mineral Metabolism

    Background:

    • Transmembrane calcium transfer during hemodialysis is influenced by factors like calcium gradient, plasma flow, and phosphate levels.
    • Biofiltration, a dialysis technique, involves high ultrafiltration rates.
    • Metabolic alkalosis is a known complication of biofiltration, affecting calcium levels.

    Purpose of the Study:

    • To investigate the impact of biofiltration on calcium transfer during hemodialysis.
    • To explore the relationship between biofiltration, metabolic alkalosis, and parathyroid hormone (PTH) secretion.
    • To assess potential long-term effects on bone disease in patients undergoing dialysis.

    Main Methods:

    • Analysis of transmembrane calcium transfer during hemodialysis and biofiltration.

    Related Experiment Videos

  • Monitoring of ultrafiltration rates and plasma volume flow.
  • Assessment of acid-base balance and ionized calcium/total calcium ratios.
  • Evaluation of parathyroid hormone (PTH) secretion patterns.

    • Main Results:

    • High ultrafiltration rates during biofiltration decrease net calcium transfer from dialysate to patient.
    • Prolonged metabolic alkalosis during biofiltration lowers the ionized calcium to total calcium ratio.
    • These combined effects may stimulate PTH secretion.

    Conclusions:

    • Biofiltration's impact on calcium transfer and acid-base balance could negatively affect PTH levels.
    • Increased PTH secretion may contribute to long-term bone disease in dialysis patients.
    • Further research is needed to confirm these long-term effects and optimize dialysis strategies.