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Puglia cooperative study on biofiltration.

F Mastrangelo, S Rizzelli, A Passione

    The International Journal of Artificial Organs
    |December 1, 1986
    PubMed
    Summary
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    Biofiltration improved patient outcomes in dialysis, particularly correcting metabolic acidosis. This study compared acetate and bicarbonate dialysis, finding biofiltration beneficial for hemodialysis patients.

    Area of Science:

    • Nephrology
    • Biomedical Engineering
    • Clinical Medicine

    Background:

    • Chronic kidney disease (CKD) patients often require hemodialysis.
    • Dialysis efficacy is influenced by dialysate composition and filtration methods.
    • Biofiltration (BF) offers a potential alternative or adjunct to standard dialysis.

    Purpose of the Study:

    • To evaluate the clinical efficacy of biofiltration in hemodialysis patients.
    • To compare standard acetate dialysis with bicarbonate dialysis using biofiltration.
    • To assess the impact of biofiltration on biochemical markers, acid-base balance, and neurological function.

    Main Methods:

    • A prospective study involving 60 hemodialysis patients across 12 centers.
    • Patients underwent biofiltration for 9-10.5 hours weekly using 1.2 m2 PAN dialyzers.

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  • Dialysate composition varied, with acetate used in 49 patients and bicarbonate in 11, over a 1-year treatment period.

    • Main Results:

    • Favorable clinical effects were observed in 55 out of 60 patients.
    • No significant worsening of BUN, serum creatinine, PTH, anemia, or nerve conduction velocity (NCV) was noted.
    • Biofiltration demonstrated superior correction of metabolic acidosis compared to standard acetate dialysis.

    Conclusions:

    • Biofiltration is a viable and effective treatment modality for hemodialysis patients.
    • BF offers advantages in managing metabolic acidosis, especially when compared to acetate dialysis.
    • Further research into optimizing BF protocols and patient selection is warranted.