Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biofiltration with buffer-free dialysate.

U Buoncristiani, M Ragaiolo, V Petrucci

    The International Journal of Artificial Organs
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Aesthetic use of recycled perforator flaps to correct contour deformities during abdominoplasty procedures.

    Annales de chirurgie plastique et esthetique·2025
    Same author

    Dual mobility cup in hip fracture: Indications and clinical results compared with bipolar hip arthroplasty.

    Injury·2024
    Same author

    Real-life effectiveness and safety of baricitinib in patients with severe alopecia areata: A 24-week Italian study.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2024
    Same author

    Taking care of inpatients with fragility hip fractures: the hip-padua osteosarcopenia (Hip-POS) fracture liaison service model.

    Journal of endocrinological investigation·2024
    Same author

    Trichoscopy as a monitoring tool in assessing treatment response in scalp pemphigus.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2024
    Same author

    Self-induced nail disorders (SINDs): What do we know so far?

    Annales de dermatologie et de venereologie·2023
    Same journal

    Therapeutic plasma exchange added to CRRT combined with hemoperfusion in wasp sting-associated AKI: A multicenter retrospective cohort study.

    The International journal of artificial organs·2026
    Same journal

    Development of an early prediction model for ICU-acquired weakness in sepsis using PNI and SII.

    The International journal of artificial organs·2026
    Same journal

    Foot care behaviors and perceived exercise benefits and barriers in diabetic hemodialysis patients.

    The International journal of artificial organs·2026
    Same journal

    First clinical experience with citrate-anticoagulated CVVHD-based low-flow ECCO<sub>2</sub>R in severe hypercapnic respiratory failure.

    The International journal of artificial organs·2026
    Same journal

    Carboxyhemoglobin levels for the detection of hemolysis in patients supported by left ventricular assist devices: A case series.

    The International journal of artificial organs·2026
    Same journal

    Evaluation of arteriovenous fistulas of obtuse anastomosis in reducing thrombosis using computational fluid dynamics.

    The International journal of artificial organs·2026
    See all related articles

    Acetate-free biofiltration, using bicarbonate reinfusion, is a safe and feasible alternative to standard hemodialysis. This method may offer improved acid-base control and cardiovascular stability in patients undergoing renal replacement therapy.

    Area of Science:

    • Nephrology
    • Renal Replacement Therapy
    • Biochemistry

    Background:

    • Standard biofiltration uses acetate-containing dialysate, which may cause adverse effects.
    • Acetate's role in biofiltration is questioned due to potential metabolic, cardiovascular, and biological side effects.
    • Bicarbonate is already infused during standard biofiltration, suggesting acetate may be redundant.

    Purpose of the Study:

    • To evaluate the feasibility and safety of an acetate-free biofiltration technique.
    • To assess the potential benefits of using bicarbonate reinfusion without acetate in the dialysate.
    • To investigate if this modified technique offers advantages over standard biofiltration.

    Main Methods:

    • Developed and implemented an acetate-free biofiltration protocol.

    Related Experiment Videos

  • Increased bicarbonate concentration in the reinfusate solution.
  • Conducted a clinical trial over 20 months involving 4 patients.

    • Main Results:

    • The acetate-free biofiltration technique was proven feasible and safe over a 20-month period.
    • Patients tolerated the procedure well, with no significant adverse events reported.
    • Preliminary findings suggest potential advantages in acid-base balance and cardiovascular stability.

    Conclusions:

    • Acetate-free biofiltration with bicarbonate reinfusion is a viable and safe alternative to standard biofiltration.
    • This approach may mitigate risks associated with acetate exposure.
    • Further research is warranted to confirm the suggested benefits of improved acid-base control and cardiovascular stability.