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Related Experiment Video

Updated: Sep 23, 2025

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Hereditary Colorectal Cancer.

Heather Hampel¹, Matthew F Kalady², Rachel Pearlman³

¹Division of Human Genetics, Biospecimen Research, Internal Medicine, The Ohio State University Comprehensive Cancer Center, 2012 Kenny Road, Room 257, Columbus, OH 43221, USA.

Hematology/Oncology Clinics of North America

|May 16, 2022

Summary

This summary is machine-generated.

Approximately 10-16% of colorectal cancer patients harbor pathogenic variants in cancer susceptibility genes. These genetic alterations define hereditary colorectal cancer syndromes, categorized into nonpolyposis and polyposis types.

Keywords:

Cancer Colorectal Hereditary Lynch syndrome Polyposis

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Area of Science:

Genetics
Oncology
Hereditary Cancer Syndromes

Background:

10-16% of colorectal cancer (CRC) patients possess pathogenic variants in cancer susceptibility genes.
These variants can be in CRC-associated genes or non-CRC-associated genes.
Hereditary CRC syndromes are broadly classified into nonpolyposis and polyposis categories.

Purpose of the Study:

To detail the classification and characteristics of hereditary colorectal cancer syndromes.
To provide a comprehensive overview of genetic predispositions to colorectal cancer.

Main Methods:

Review and synthesis of existing literature on hereditary colorectal cancer.
Classification of syndromes based on clinical presentation and genetic factors.
Detailed description of nonpolyposis and polyposis conditions.

Main Results:

Nonpolyposis syndromes are subcategorized into those with and without defective mismatch repair.
Polyposis syndromes are classified by predominant histology: adenomatous, hamartomatous, serrated, and mixed.
The study provides a detailed description of each hereditary colorectal cancer syndrome.

Conclusions:

Understanding the genetic basis of colorectal cancer is crucial for diagnosis and management.
Accurate classification of hereditary syndromes aids in risk assessment and targeted therapies.
This work serves as a detailed resource for hereditary colorectal cancer conditions.