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The role of histone deacetylase 3 in breast cancer

Rezgar Rahbari1, Yousef Rasmi1, Mohammad Hassan Khadem-Ansari2

  • 1Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Medical Oncology (Northwood, London, England)
|May 16, 2022
PubMed

Insights

Histone Deacetylase (HDAC) 3 plays a role in cancer progression by altering gene expression. Inhibiting HDAC3 shows promise as a therapeutic strategy for breast cancer (BC).

Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • Histone Deacetylase (HDAC) 3 is implicated in cancer development through gene expression and protein activity modulation.
  • HDAC enzymes are increasingly recognized as potential therapeutic targets in oncology.
  • Upregulation of HDAC3 in breast cancer (BC) suggests its oncogenic role.

Purpose of the Study:

  • To review the function of HDAC3 in breast cancer pathogenesis.
  • To highlight current HDAC3 inhibitors for breast cancer therapy.

Main Methods:

  • Literature review of studies on HDAC3 in breast cancer.
  • Analysis of HDAC3's role in gene regulation and protein activity.
  • Survey of existing HDAC3 inhibitors and their therapeutic potential.

Main Results:

  • HDAC3 contributes to cancer progression by affecting gene expression.
  • HDAC3 inhibition is a promising therapeutic avenue for breast cancer.
  • Various HDAC3 inhibitors have been developed.

Conclusions:

  • HDAC3 is a significant factor in breast cancer development and progression.
  • Targeting HDAC3 offers a viable therapeutic strategy for breast cancer patients.
  • Further research into HDAC3 inhibitors is warranted for effective breast cancer treatment.
Keywords:
Breast cancerHDACHDAC3HDAC3 inhibitors

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