Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

5.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.7K
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

13.9K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.9K
Thermoregulation01:26

Thermoregulation

1.4K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
1.4K
Thermal Stress01:09

Thermal Stress

2.6K
If the temperature of an object is changed while it is prevented from expanding or contracting, the object is subjected to stress. The stress is compressive if the object expands in the absence of constraint and tensile if it contracts. This stress resulting from temperature change is known as thermal stress. It can be quite large and can cause damage. To avoid this stress, engineers may design components so they can expand and contract freely. For instance, on highways, gaps are deliberately...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circadian screening of neutrophils identifies therapeutic targets in multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Age at menarche association with metabolic, reproductive, and sociodemographic factors: a population-based cross-sectional analysis using an outcome-wide framework in Geneva, Switzerland.

European journal of public health·2026
Same author

Precision medicine's inevitable trajectory toward rare-disease-sized cohorts: implications for machine learning and deep learning.

The Lancet. Digital health·2026
Same author

Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes.

Nature cancer·2026
Same author

Age-related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Neuronal STAT1 as a phase switch from antiviral defense to synaptopathy in encephalitis.

Trends in neurosciences·2026

Related Experiment Video

Updated: Sep 23, 2025

Single-Animal, Single-Tube RNA Extraction for Comparison of Relative Transcript Levels via qRT-PCR in the Tardigrade Hypsibius exemplaris
08:11

Single-Animal, Single-Tube RNA Extraction for Comparison of Relative Transcript Levels via qRT-PCR in the Tardigrade Hypsibius exemplaris

Published on: January 3, 2025

580

Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal

Noushin Hadadi1,2, Martina Spiljar1,2, Karin Steinbach3

  • 1Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Medical Universitaire (CMU), University of Geneva, Geneva, Switzerland.

Elife
|May 17, 2022
PubMed
Summary

Thermal adaptation impacts gene expression across multiple tissues. This study reveals significant tissue-specific responses to temperature changes, offering insights into whole-body biological programming.

Keywords:
adipose tissuecoldcomputational biologygeneticsgenomicsmetabolismmousemulti-tissue transcriptomicssystems biologytemperaturewarm

More Related Videos

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
08:23

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

17.5K
Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting
11:11

Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting

Published on: March 17, 2023

2.4K

Related Experiment Videos

Last Updated: Sep 23, 2025

Single-Animal, Single-Tube RNA Extraction for Comparison of Relative Transcript Levels via qRT-PCR in the Tardigrade Hypsibius exemplaris
08:11

Single-Animal, Single-Tube RNA Extraction for Comparison of Relative Transcript Levels via qRT-PCR in the Tardigrade Hypsibius exemplaris

Published on: January 3, 2025

580
Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
08:23

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

17.5K
Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting
11:11

Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting

Published on: March 17, 2023

2.4K

Area of Science:

  • Physiology
  • Molecular Biology
  • Genomics

Background:

  • Thermal adaptation influences thermogenesis and mitochondrial activity in adipose tissues.
  • It is explored as a lifestyle intervention for body weight management.
  • The impact of thermal acclimation on gene expression in non-adipose tissues is not well understood.

Purpose of the Study:

  • To systematically characterize the effects of different temperatures on gene expression across multiple tissues.
  • To compare the transcriptional responses to thermal changes in various organs.
  • To understand tissue-specific adaptations to temperature in a whole-organism context.

Main Methods:

  • Comparative multi-tissue RNA sequencing was performed on mice exposed to 10 °C, 22 °C, and 34 °C.
  • Gene expression profiles were analyzed in a panel of organs including spleen, bone marrow, brain, liver, and adipose tissues.
  • Gene Ontology (GO) enrichment analysis was used to identify functional pathways affected by temperature.

Main Results:

  • Transcriptional responses to temperature alterations demonstrated high tissue-specificity at both the gene and GO enrichment levels.
  • This tissue-specificity was not dictated by the inherent basic gene expression patterns of the organs.
  • Significant differences in gene expression were observed across various tissues in response to environmental temperature.

Conclusions:

  • Thermal adaptation induces distinct, tissue-specific transcriptional programming throughout the body.
  • Understanding these tissue-specific responses is crucial for a comprehensive view of temperature-mediated biological effects.
  • The study provides an integrative transcriptional framework for analyzing whole-organism adaptation to temperature.