Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of genitourinary toxicity following bladder outlet obstruction procedures in patients before versus after radiotherapy for localized prostate cancer: a retrospective cohort study using the TriNetX database.

Prostate cancer and prostatic diseases·2026
Same author

Residency Exposure to URPS (Urogynecology and Reconstructive Pelvic Surgery)-Trained Attendings Increase the Number of Female Pelvic Procedures Performed by General Urologists After Graduation.

Neurourology and urodynamics·2026
Same author

Brain Activity Changes During Bladder Filling in Women With Overactive Bladder After Percutaneous Tibial Neuromodulation.

Neurourology and urodynamics·2026
Same author

Novel non-proprietary subcutaneous testosterone replacement therapy as a treatment for primary hypogonadism in men.

The journal of sexual medicine·2025
Same author

Urologists Self-Report Rates of Postprostatectomy Incontinence and Referral Patterns for Treatment.

Urology practice·2025
Same author

The Feasibility and Safety of the Glean Urodynamics System: The Modern Urodynamics System Efficacy Study.

Journal of endourology·2025

Related Experiment Video

Updated: Sep 23, 2025

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

14.7K

Initial experience using the Axonics sacral neuromodulation system in patients with multiple sclerosis.

Annie Chen1, Anjali Kapur1, Spencer Mossack1

  • 1Department of Urology, Stony Brook University Hospital, Stony Brook, New York, USA.

Neurourology and Urodynamics
|May 17, 2022
PubMed
Summary

The Axonics System offers significant improvement for multiple sclerosis patients with urge urinary incontinence, allowing for necessary MRI scans. This sacral neuromodulation therapy enhances quality of life for MS patients experiencing urinary dysfunction.

Keywords:
multiple sclerosisoveractive bladdersacral neuromodulationurinary frequencyurinary urge incontinence

More Related Videos

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

17.5K
Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
04:04

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

380

Related Experiment Videos

Last Updated: Sep 23, 2025

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

14.7K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

17.5K
Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
04:04

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

380

Area of Science:

  • Urology
  • Neurology
  • Biomedical Engineering

Background:

  • Sacral neuromodulation (SNM) is a third-line therapy for urge urinary incontinence (UUI), urgency, and nonobstructive urinary retention.
  • Multiple sclerosis (MS) patients frequently experience neurogenic lower urinary tract dysfunction (NLUTD).
  • Traditional SNM devices are incompatible with MRI, hindering routine disease monitoring in MS patients.

Purpose of the Study:

  • To evaluate the efficacy of the Axonics System, an MRI-conditional SNM device, in improving symptoms of UUI in MS patients.
  • To assess the impact of Axonics SNM on the quality of life for MS patients with NLUTD.

Main Methods:

  • A cohort of 15 MS patients who underwent Axonics SNM implantation for UUI between December 2019 and January 2021 were included.
  • Patients' demographics and validated questionnaire scores (UDI-6, IIQ-7, GRA) were collected before and after implantation.
  • Follow-up averaged 121 days post-implantation.

Main Results:

  • 12 out of 15 MS patients reported improvement in UUI symptoms, with significant reductions in UDI-6 and IIQ-7 scores (p < 0.0001 and p < 0.001, respectively).
  • Significant improvements were noted in UDI-6 subcategories including stress urinary incontinence and voiding difficulty.
  • IIQ-7 scores showed significant improvements in travel, social, and emotional well-being, with an average GRA score of 6 (moderately improved).

Conclusions:

  • The Axonics System demonstrates significant initial symptomatic improvement in UUI and quality of life for MS patients.
  • The MRI-conditional safety of the Axonics System is crucial for MS patients requiring regular disease monitoring.
  • Further research is warranted to establish long-term outcomes and durability of the Axonics System in this population.