Hybrid Stents Based on Magnetic Hydrogels for Biomedical Applications

Tremendous attention has been given to hydrogels due to their mechanical and physical properties. Hydrogels are promising biomaterials due to their high biocompatibility. Magnetic hydrogels, which are based on hydrogel incorporated magnetic nanoparticles, have been proposed in biomedical applications. The advantages of magnetic hydrogels are that they can easily respond to externally applied magnetic fields and prevent the leakage of magnetic nanoparticles in the surrounding area. Herein, a prototype hybrid stent of magnetic hydrogel was fabricated, characterized, and evaluated for magnetic hyperthermia treatment. First, magnetic hydrogel was produced by a solution of alginate with magnetic nanoparticles in a bath of calcium chloride (5-15 mg mL^-1) in order to achieve the external gelation and optimize the heating rate. The increased concentration (1-8 mg mL^-1) of magnetic nanoparticles inside the hydrogel resulted in almost zero leakage of iron oxide nanoparticles after 15 days, guaranteeing that they can be used safely in biomedical applications. Thus, magnetic hybrid stents, which are based on the magnetic hydrogels, were developed in a simple way and were evaluated both in an agarose phantom model and in an ex vivo tissue sample at 30 mT and 765 kHz magnetic hyperthermia conditions to examine the heating efficiency. In both cases, hyperthermia results indicate excellent heat generation from the hybrid stent and facile temperature control via tuning magnetic nanoparticle concentration (2-8 mg mL^-1). This study can be a promising method that promotes spatially thermal distribution in cancer treatment or restenosis treatment of hollow organs.