Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An integrated system for interstitial 192Ir implants.

J D Bourland, K L Reynolds, E L Chaney

    International Journal of Radiation Oncology, Biology, Physics
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Immune checkpoint blockers in solid organ transplant recipients and cancer: the INNOVATED cohort.

    ESMO open·2024
    Same author

    Effects of high incubation temperature on tight junction proteins in the yolk sac and small intestine of embryonic broilers.

    Poultry science·2023
    Same author

    Histopathologically-confirmed lichenoid eruptions from immune checkpoint inhibitor therapy: a retrospective cohort analysis.

    The British journal of dermatology·2021
    Same author

    The positive effect of immune checkpoint inhibitor-induced thyroiditis on overall survival accounting for immortal time bias: a retrospective cohort study of 6596 patients.

    Annals of oncology : official journal of the European Society for Medical Oncology·2021
    Same author

    Effect of dermatological consultation on survival in patients with checkpoint inhibitor-associated cutaneous toxicity.

    The British journal of dermatology·2021
    Same author

    Diagnostic and therapeutic differences between immune checkpoint inhibitor-induced and idiopathic bullous pemphigoid: a cross-sectional study.

    The British journal of dermatology·2020
    Same journal

    Single Percussive Ventilation Breath-hold Imaging and Delivery in Lung Tumor Stereotactic Ablative Radiation Therapy: Initial Observations From a Prospective Clinical Trial.

    International journal of radiation oncology, biology, physics·2026
    Same journal

    Proton beam therapy in nonmetastatic rhabdomyosarcoma: Outcome, prognostic factors and the effect of timing of radiation therapy.

    International journal of radiation oncology, biology, physics·2026
    Same journal

    Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

    International journal of radiation oncology, biology, physics·2026
    Same journal

    Gastrointestinal Motility-Induced Interplay in Pancreas Proton Therapy: Motion Simulation and Dosimetric Impact.

    International journal of radiation oncology, biology, physics·2026
    Same journal

    Intra-fractional Voxel-wise Anatomical Motion Tracking Guided by Multimodal Respiratory Surrogates in Radiotherapy: Framework Development and Multi-Center Validation.

    International journal of radiation oncology, biology, physics·2026
    Same journal

    A Gaussian-based planning approach for robust dose-escalated stereotactic body proton therapy.

    International journal of radiation oncology, biology, physics·2026
    See all related articles

    A new integrated system simplifies interstitial 192Ir (Iridium-192) brachytherapy by streamlining preparation, afterloading, and removal of radioactive sources. This novel approach enhances safety for personnel and patient comfort during treatments like head/neck and breast cancer.

    Area of Science:

    • Medical Physics
    • Radiation Oncology
    • Brachytherapy

    Background:

    • Interstitial brachytherapy using Iridium-192 (192Ir) sources is a common cancer treatment.
    • Current methods for handling and implanting 192Ir strands can pose risks of radiation exposure and patient discomfort.
    • A need exists for improved, integrated systems for 192Ir brachytherapy procedures.

    Purpose of the Study:

    • To develop and evaluate an integrated system for the preparation, afterloading, and removal of interstitial 192Ir strands.
    • To reduce personnel radiation exposure and minimize patient discomfort during brachytherapy.
    • To create a versatile system applicable to various implant techniques and anatomical sites.

    Main Methods:

    • An "assembly line" process with shielded equipment was designed for efficient strand preparation, including a handling block for measuring and cutting.

    Related Experiment Videos

  • Quick-release devices, specialized afterloading tubing/catheters with Luer lock adapters, and an injection cap were developed for afterloading and removal.
  • The system supports both blind-end and through-and-through implant techniques, allowing rapid insertion and secure locking of 192Ir strands without crimping.
  • Main Results:

    • The integrated system successfully facilitated preparation, afterloading, and removal of interstitial 192Ir strands in over 100 cases without incident.
    • Personnel exposure risks were reduced, and patient comfort was enhanced compared to conventional methods.
    • The system demonstrated versatility, accommodating various implant types and anatomical locations, including head/neck, breast, and vaginal wall treatments.

    Conclusions:

    • The developed integrated system offers an efficient and safe method for interstitial 192Ir brachytherapy.
    • The system's design minimizes radiation exposure and patient discomfort, improving the overall brachytherapy experience.
    • This approach allows for repeatable and reliable implantation and removal of 192Ir sources, with potential for reuse after cleaning.