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Efficacy of Hemoperfusion in Severe and Critical Cases of COVID-19

Ilad Alavi Darazam1,2, Muhanna Kazempour3, Mohamad Amin Pourhoseingholi4

  • 1Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Blood Purification
|May 17, 2022
PubMed

Insights

Hemoperfusion therapy in severe COVID-19 patients significantly lowered mortality rates and improved oxygen levels. This extracorporeal therapy offers a potential benefit for critically ill patients with COVID-19.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Extracorporeal Therapies

Background:

  • Severe COVID-19 is characterized by uncontrolled inflammatory mediator production, leading to multiple organ dysfunction.
  • Extracorporeal therapies offer a potential strategy to mitigate excessive inflammation and support organ function in critically ill patients.

Purpose of the Study:

  • To investigate the effectiveness of hemoperfusion combined with standard therapy in critically ill COVID-19 patients.

Main Methods:

  • A retrospective, single-center, matched control study involving 128 COVID-19 patients.
  • Patients received either hemoperfusion plus standard therapy or standard therapy alone.
  • Hemoperfusion was performed using Jafron© (HA330) or CytoSorb® 300 cartridges.

Main Results:

  • The hemoperfusion group (55 patients) showed a significantly lower mortality rate (67.3%) compared to the matched control group (73 patients, 89%; p=0.002).
  • Median length of ICU stay was longer in the hemoperfusion group (12 days) versus the control group (8 days; p<0.001).
  • Hemoperfusion was associated with improved final oxygen saturation (SPO2) and lower partial pressure of carbon dioxide (PaCO2).

Conclusions:

  • Hemoperfusion in conjunction with standard therapy may reduce mortality in critically ill COVID-19 patients.
  • This extracorporeal approach appears to improve key respiratory parameters, including SPO2 and PaCO2.
Abstract

Keywords:
Acute respiratory distress syndromeCOVID-19Cytokine stormHemoperfusionSARS-CoV-2

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