Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A flap mechanics testbed for skin reconstructive surgery: Evaluating the mechanical interaction between flap design and anisotropy.

Acta biomaterialia·2026

Same author

A data-driven framework for modeling the dendritic spine continuum using dimensionality reduction and clustering toward understanding synaptic plasticity.

PloS one·2026

Same author

A Fully Biological Gas-Exchange Membrane toward a Biofabricated, Booster Lung.

ACS biomaterials science & engineering·2026

Same author

Impacts of Sterilization Method on Material Properties of 3D Printable Resins With Prolonged Exposure to Cell Culture Environments.

Journal of biomechanical engineering·2026

Same author

Reliable AI Platform for Monitoring BCI Caused Brain Injury and Providing Real-Time Protection.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.

Computer methods in applied mechanics and engineering·2025

Same journal

Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

Scientific reports·2026

Same journal

Microbial contamination of donor corneas and post-keratoplasty endophthalmitis: a comparison between Japanese and U.S. eye banks using cold storage.

Scientific reports·2026

Same journal

Prevalence and contributing factors of virological non-suppression among adult patients on first-line antiretroviral therapy in tertiary hospitals in Ethiopia.

Scientific reports·2026

Same journal

An in vitro comparison of color stability between alkasite and different restorative materials in various staining solutions.

Scientific reports·2026

Same journal

Toward accessible mRNA LNP formulation: systematic evaluation of mixing strategies and key parameters.

Scientific reports·2026

Same journal

A network analysis of personality traits, mentalizing, and psychological health in Chinese college students.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 23, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Modeling neuron growth using isogeometric collocation based phase field method.

Kuanren Qian¹, Aishwarya Pawar², Ashlee Liao¹

¹Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, 15213, USA.

Scientific Reports

|May 17, 2022

Summary

This summary is machine-generated.

This study introduces a new computational framework for modeling neuron growth, simulating key stages like neurite outgrowth and axon differentiation using tubulin dynamics. The open-source software package accurately reproduces neuron morphologies, aiding future research into neural networks.

More Related Videos

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain

Published on: August 9, 2024

Localizing Protein in 3D Neural Stem Cell Culture: a Hybrid Visualization Methodology

Localizing Protein in 3D Neural Stem Cell Culture: a Hybrid Visualization Methodology

Published on: December 19, 2010

Related Experiment Videos

Last Updated: Sep 23, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain

Published on: August 9, 2024

Localizing Protein in 3D Neural Stem Cell Culture: a Hybrid Visualization Methodology

Localizing Protein in 3D Neural Stem Cell Culture: a Hybrid Visualization Methodology

Published on: December 19, 2010

Area of Science:

Computational neuroscience
Biophysics
Developmental biology

Background:

Neuron morphology is highly variable, complicating mathematical modeling of neuron growth.
Understanding neuron growth is crucial for neuroscience and developmental biology.

Purpose of the Study:

To develop a novel computational framework for simulating neuron growth.
To model various stages of neuron development, including neurite outgrowth and differentiation.
To investigate the role of tubulin dynamics in neuron morphology.

Main Methods:

Utilized a phase field method combined with isogeometric collocation.
Developed an open-source software package named "NeuronGrowth_IGAcollocation".
Modeled stages: lamellipodia formation, initial neurite outgrowth, axon differentiation, and dendrite formation.

Main Results:

Successfully simulated different stages of neuron growth, including the effect of tubulin.
Demonstrated qualitatively and quantitatively similar reproduction of neuron morphologies compared to experimental data.
The framework allows for extension towards modeling neurite network formation.

Conclusions:

The proposed phase field model with isogeometric collocation provides a robust computational framework for neuron growth simulation.
The "NeuronGrowth_IGAcollocation" software package offers a valuable tool for researchers studying neuronal development.
This approach can be extended to simulate complex neurite network formation and function.