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Updated: Sep 23, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
ERBB3 methylation and immune infiltration in tumor microenvironment of cervical cancer
Xiaoyue Yang1,2, Ying Chen2, Mei Li3
1Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangsu University, Jiefang Road 438, Zhenjiang, 212001, Jiangsu, China.
Abstract:
ERBB3, a member of the ERBB family of receptor tyrosine kinases, plays an important role in cancer, despite its lack of intrinsic carcinogenic mechanism of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Research on bioinformatics methods through multi-omics, this work proves that ERBB3 gene mutation, methylation modification have extensive regulatory mechanisms on the CESC microenvironment. We found that ERBB3 is involved in carcinogenesis of cervical cancer and is not associated with its prognosis. The carcinogenic mechanism is mainly related to the suppression of the immune system between tumor infiltrating lymphocytes (TILs) and the methylation of the RNA level. Our study indicated ERBB3 is more likely to be a carcinogenic factor than a key prognostic factor for cervical cancer. Methylation of ERBB3 may work as a checkpoint immunotherapy target in CESC, DNA methylation modification of the 4480 base pair downstream of ERBB3 transcription initiation site was the highest.
Insights
ERBB3 gene alterations influence the cervical cancer microenvironment by suppressing immune cells. Methylation of ERBB3 shows potential as an immunotherapy target for cervical squamous cell carcinoma and endocervical adenocarcinoma.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The ERBB3 gene, part of the ERBB receptor tyrosine kinase family, is implicated in various cancers.
- Its specific role and mechanisms in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) require further elucidation.
Purpose of the Study:
- To investigate the role of ERBB3 gene mutations and methylation in the CESC tumor microenvironment.
- To determine if ERBB3 is a carcinogenic factor or a prognostic marker in cervical cancer.
Main Methods:
- Utilized multi-omics bioinformatics approaches to analyze ERBB3 alterations.
- Examined the association between ERBB3 modifications, the tumor microenvironment, and immune cell infiltration.
Main Results:
- ERBB3 gene mutations and methylation extensively regulate the CESC microenvironment.
- ERBB3 is involved in cervical cancer development, primarily through immune system suppression and RNA methylation, rather than prognosis.
- Specific DNA methylation modifications downstream of ERBB3 were identified as the most significant.
Conclusions:
- ERBB3 acts as a carcinogenic factor in cervical cancer, not a prognostic one.
- ERBB3 methylation presents a potential target for immune checkpoint immunotherapy in CESC.
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