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Updated: Sep 22, 2025

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Anionic Polymerization of para-(1-Ethoxy ethoxy)styrene: Rapid Access to Poly(p-hydroxystyrene) Copolymer
Adrian Natalello1,2, Christoph Tonhauser1,2, Holger Frey1
1Institute of Organic Chemistry, Johannes Gutenberg-University (JGU), Duesbergweg 10-14, 55099 Mainz, Germany.
Abstract:
Living anionic polymerization of para-(1-ethoxy ethoxy)styrene (pEES) resulting in molecular weights between 2700 and 69 000 g mol-1 and polydispersity indices ≤1.09 is introduced. PpEES can be used as a precursor for the synthesis of well-defined poly(p-hydroxystyrene) (PHS) architectures, enabling facile and rapid acidic deprotection at room temperature within a few minutes. In addition, a series of block copolymers containing pEES and 2-vinylpyridine (2VP) have been synthesized by anionic block copolymerization, with varied block ratios (X2VP) between 0.13 and 0.83. Characterization by 1H NMR spectroscopy, size exclusion chromatography (SEC), and differential scanning calorimetry (DSC) was carried out, and all polymers have been deprotected, leading to the respective PHS-b-P2VP block copolymers. Furthermore, PHS-b-P2VP has been used as a macroinitiator for the anionic ring-opening polymerization of ethylene oxide (EO) to generate ((PHS-g-PEO51)13-b-P2VP40) graft-block copolymers.
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