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Updated: Sep 22, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
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Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications

Bao-Jie Zhang1, Deng Chen1, Frank J Dekker1

  • 1University of Groningen, Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen 9713 AV, The Netherlands.

Cancer Drug Resistance (Alhambra, Calif.)
|May 18, 2022
PubMed
Summary

Histone modifications epigenetically regulate gene transcription and are key in cancer development. Inhibiting these aberrant modifications can enhance cancer therapies like tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

Keywords:
Epigeneticsapoptosishistone modificationselective epigenetic inhibitorstumor necrosis factor-related apoptosis-inducing ligand

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