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Updated: Sep 22, 2025
12:16
A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
14.9K
Barriers to achieving a cure in lymphoma.
Swetha Kambhampati1, Joo Y Song2, Alex F Herrera1
1Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.
Cancer Drug Resistance (Alhambra, Calif.)
|May 18, 2022
Summary
Understanding drug resistance in lymphoma is key to developing new treatments. This review covers advances in lymphoma therapies and strategies to overcome resistance mechanisms for better patient outcomes.
Area of Science:
- Oncology
- Hematology
- Immunology
Background:
- Lymphoma encompasses diverse subtypes with unique molecular drivers.
- Novel targeted therapies and immunotherapies have advanced lymphoma treatment.
- Therapy relapse remains a significant challenge, often due to drug resistance.
Purpose of the Study:
- To review recent advances in lymphoma therapies.
- To discuss mechanisms of drug resistance across various treatment modalities.
- To explore strategies for overcoming resistance in lymphoma treatment.
Main Methods:
- Review of recent literature on lymphoma therapies.
- Analysis of targeted therapies, immunotherapies, and cellular therapies.
- Discussion of genetic and cellular principles of drug resistance.
Main Results:
- Recent advances include targeted therapies, monoclonal antibodies, antibody-drug conjugates, cellular therapy, bispecific antibodies, and checkpoint inhibitors.
- Drug resistance presents common genetic and cellular principles across therapies.
- Unique resistance mechanisms exist for specific therapy classes.
Conclusions:
- Overcoming drug resistance is crucial for improving lymphoma treatment efficacy.
- Personalized treatment algorithms and optimal therapy sequencing are needed.
- Further research into resistance mechanisms will guide the development of novel therapeutic strategies.
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