Related Experiment Video

Updated: Sep 22, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K

Epigenetic modulation in sensitizing metastatic sarcomas to therapies and overcoming resistance

Jeff Rytlewski1, Qierra R Brockman1, Rebecca D Dodd1,2

  • 1Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.

Cancer Drug Resistance (Alhambra, Calif.)
|May 18, 2022
PubMed

Insights

Altering the epigenome offers a promising strategy to improve outcomes for patients with sarcoma, a rare cancer. Understanding epigenetic changes can guide targeted therapies and overcome chemotherapy resistance.

Area of Science:

  • Oncology
  • Epigenetics
  • Genomics

Background:

  • Sarcomas are rare, aggressive cancers originating from mesenchymal tissues.
  • Metastatic sarcomas are associated with poor clinical outcomes.
  • Epigenetic alterations are implicated in sarcoma development and progression.

Purpose of the Study:

  • To review genomic and epigenetic changes in sarcomas.
  • To discuss the impact of epigenetic modifications on clinical outcomes.
  • To explore therapeutic strategies targeting the epigenome in sarcoma.

Main Methods:

  • Review of existing literature on sarcoma epigenetics.
  • Analysis of genomic and epigenomic data in sarcomas.
  • Evaluation of clinical trials targeting epigenetic pathways.

Main Results:

  • Sarcomas exhibit diverse epigenetic alterations contributing to oncogenesis.
  • Epigenetic modifications influence treatment response and chemotherapy resistance.
  • Targeting epigenetic mechanisms shows potential for reversing resistance.

Conclusions:

  • Modulating the epigenome is a viable strategy to improve sarcoma treatment outcomes.
  • Further research into epigenetic biomarkers is crucial for developing targeted therapies.
  • Future clinical studies should focus on epigenetic phenotypes of sarcoma subtypes.
Keywords:
Epigeneticsmetastasisresistancesarcoma

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