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Long non-coding RNAs regulation of therapeutic resistance

Susan Tsang1,2, Tajhal Patel2, Jason T Yustein1,2

  • 1Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine, Houston, TX 77030, USA.

Cancer Drug Resistance (Alhambra, Calif.)
|May 18, 2022
PubMed

Insights

Long non-protein coding RNAs (lncRNAs) regulate cell signaling and cancer. Their dysregulation contributes to cancer progression and resistance to therapies like chemotherapy and targeted treatments.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Non-protein coding RNAs regulate crucial cell processes.
  • Long non-protein coding RNAs (lncRNAs) are a key subtype.
  • lncRNAs impact cell proliferation, metastasis, and cancer stem cell traits.

Purpose of the Study:

  • To review the role of lncRNA dysregulation in various cancers.
  • To highlight mechanisms of therapeutic resistance driven by lncRNAs.
  • To discuss the impact on chemotherapy and targeted/hormone therapies.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of lncRNA functions in cancer cell biology.
  • Examination of molecular mechanisms underlying therapeutic resistance.

Main Results:

  • lncRNA dysregulation is implicated in a wide range of malignancies.
  • lncRNAs significantly contribute to resistance against chemotherapy.
  • lncRNAs also mediate resistance to targeted and hormone therapies.

Conclusions:

  • lncRNAs are critical regulators in cancer development and progression.
  • Targeting lncRNAs may overcome therapeutic resistance.
  • Further research into lncRNA mechanisms is essential for novel cancer treatments.
Keywords:
Long non-protein coding RNAand microRNA spongecancerchemotherapeutic resistancehormone therapytarget therapeutics

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