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Updated: Sep 22, 2025

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
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Robotic Tissue Sampling for Safe Post-Mortem Biopsy in Infectious Corpses.

Maximilian Neidhardt1, Stefan Gerlach1, Robin Mieling1

  • 1Institute of Medical Technology and Intelligent Systems, Hamburg University of Technology 21073 Hamburg Germany.

IEEE Transactions on Medical Robotics and Bionics
|May 18, 2022
PubMed
Summary
This summary is machine-generated.

Minimally invasive robotic post-mortem biopsy (RPMB) reduces disease transmission risk during tissue sampling. This CT-guided system enhances accuracy for pathological and microbiological analysis, crucial for pandemic response strategies.

Keywords:
COVID-19Collaborative robotforensic medicinemedical roboticspath planning

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Area of Science:

  • Pathology
  • Legal Medicine
  • Robotics
  • Medical Imaging

Background:

  • Histopathological and microbiological analysis of deceased individuals is vital for pandemic treatment strategies, like during COVID-19.
  • Conventional autopsies pose disease transmission risks and may face family objections.
  • Minimally invasive techniques are needed to safely obtain tissue samples from infected deceased.

Purpose of the Study:

  • To introduce and evaluate a novel robotic system for minimally invasive post-mortem tissue sampling.
  • To minimize disease transmission risks associated with traditional autopsies.
  • To enhance the accuracy of tissue sampling for diagnostic purposes.

Main Methods:

  • A flexible robotic system guided by CT imaging was developed for post-mortem biopsy.
  • An automated planning system calculated optimal insertion points, avoiding bone collisions.
  • A custom end effector was designed for robotic needle insertion and tissue extraction.
  • The robotic post-mortem biopsy (RPMB) system was tested on 20 human corpses, including 5 infected with SARS-CoV-2.

Main Results:

  • The robotic system successfully performed minimally invasive biopsies on deceased individuals.
  • Mean planning time, including robot path planning, was 5.72±1.67 seconds.
  • Mean needle placement accuracy was 7.19±4.22 mm, demonstrating high precision.

Conclusions:

  • The robotic post-mortem biopsy system offers a safer and more accurate alternative to conventional autopsies.
  • This technology can aid in developing effective treatment strategies during pandemics by providing critical diagnostic information.
  • Minimally invasive robotic biopsy is a feasible and valuable tool in forensic pathology and infectious disease research.