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Glymphatic system dysfunction in patients with cluster headache.

Jinseung Kim1, Dong Ah Lee2, Ho-Joon Lee3

  • 1Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Brain and Behavior
|May 18, 2022
PubMed
Summary

Cluster headache patients show impaired glymphatic system function, indicated by a lower diffusion tensor imaging analysis with perivascular space (DTI-ALPS) index. This finding suggests a potential link between glymphatic dysfunction and cluster headache pathophysiology.

Keywords:
cluster headachediffusion tensor imagingglymphatic system

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Area of Science:

  • Neuroscience
  • Radiology

Background:

  • Cluster headache is a debilitating neurological disorder.
  • The glymphatic system clears waste from the brain.
  • Glymphatic system dysfunction is implicated in various neurological conditions.

Purpose of the Study:

  • To investigate glymphatic system function in patients with cluster headache.
  • To compare glymphatic function between cluster headache patients and healthy controls using advanced imaging techniques.

Main Methods:

  • Recruited 14 cluster headache patients and 23 healthy controls.
  • Utilized brain magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI).
  • Calculated the diffusion tensor imaging analysis with perivascular space (DTI-ALPS) index using MRIcron and DSI studio.

Main Results:

  • Cluster headache patients exhibited a significantly lower DTI-ALPS index (1.586) compared to healthy controls (1.786, p=0.044).
  • A negative correlation was observed between DTI-ALPS index and age in cluster headache patients (r=-0.549, p=0.042).
  • No significant association was found between DTI-ALPS index and disease duration or headache intensity.

Conclusions:

  • Lower DTI-ALPS index in cluster headache patients suggests impaired glymphatic system function.
  • Glymphatic dysfunction may play a role in the pathophysiology of cluster headache.
  • Further research is needed to elucidate the relationship between glymphatic system dysfunction and cluster headache.