[Retracted] MicroRNA‑133a acts as a tumour suppressor in breast cancer through targeting LASP1

Yanmin Sui1, Xiaolei Zhang1, Honglan Yang1

  • 1Department of Oncology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

Oncology Reports
|May 18, 2022
PubMed

Insights

This paper has been retracted due to concerns about duplicated western blotting data. The editors found similarities to previously published or submitted data, leading to its removal from Oncology Reports.

Area of Science:

  • Biomedical research
  • Oncology
  • Scientific publishing

Context:

  • Concerns were raised regarding data duplication in western blotting assays.
  • Similar data appeared in other publications by different authors.
  • The contentious data was previously published or under consideration elsewhere.

Purpose:

  • To address concerns about data integrity and scientific misconduct.
  • To maintain the standards of scientific publishing.
  • To inform the readership about the retraction of a published article.

Summary:

  • The Editors of Oncology Reports retracted a paper due to duplicated western blotting data (Figs. 5B, 5E, 6C, 7A).
  • The data was found to be strikingly similar to previously published or submitted material.
  • Authors did not provide an explanation despite requests.

Impact:

  • Retraction upholds scientific integrity and trust in published research.
  • Ensures accurate dissemination of oncological research findings.
  • Alerts researchers to potential issues with the cited publication.

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.3K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.0K