Related Experiment Video
Updated: Sep 22, 2025
05:41
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
757
Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis
Renaud Ciappuccini1,2, Virginie Saguet-Rysanek3, Marine Dorbeau3
1Department of Nuclear Medicine and Thyroid Unit, François Baclesse Cancer Centre, Caen, France.
European Thyroid Journal
|May 18, 2022
Summary
18F-Fluorocholine (18FCH) PET/CT shows high uptake in chronic autoimmune thyroiditis (CAT). This uptake pattern is specific to CAT and correlates with disease severity and thyroid peroxidase antibody levels.
Area of Science:
- Nuclear Medicine
- Endocrinology
- Pathology
Background:
- 18F-Fluorocholine (18FCH) PET/CT is effective for parathyroid adenoma detection and assessing indeterminate thyroid nodules.
- Limited data exists on 18FCH uptake in chronic autoimmune thyroiditis (CAT).
Purpose of the Study:
- To evaluate 18FCH uptake in the thyroid gland in patients with CAT.
- To correlate 18FCH uptake with biological markers and histological findings.
Main Methods:
- Ancillary study of 107 patients undergoing thyroid surgery.
- 18FCH PET/CT scans performed at 20 and 60 minutes post-injection.
- Assessment of thyroid gland SUVmax and SUVmean, thyroid function tests, antibody titers, and histopathological grading of thyroiditis and fibrosis.
Main Results:
- 18% of patients had CAT, with 68% showing increased, diffuse 18FCH thyroid uptake.
- 18FCH uptake was significantly higher in patients with CAT compared to those without (P < 0.001).
- SUVmax correlated positively with thyroiditis intensity, fibrosis, and TPOAb titers.
Conclusions:
- A high and diffuse 18FCH thyroid uptake pattern is characteristic of CAT.
- This uptake pattern is highly specific for CAT.
- 18FCH uptake correlates with CAT's pathological features and TPOAb levels.
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
Related Concept Videos
01:23The Thyroid Gland
4.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.4K
01:20Synthesis and Regulation of Thyroid Hormones
5.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.2K