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Updated: Sep 22, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
[The rise of the lymphocyte clones: targeted agents strike back]
1Service d'oncologie médicale, Département d'oncologie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
Chronic lymphocytic leukemia (CLL) is an indolent lymphoproliferative disorder commonly seen in the elderly. Its diagnosis is often incidental. Treatment is not always required, and a clinical and biological follow-up may be sufficient. However, progressive CLL may result in shortened life expectancy and significant complications. It is therefore critical to precisely stratify CLL prognosis to guide therapeutic choices accordingly. Therapeutic options have largely evolved in the past years and current molecular biomarkers allow a better risk stratification, leading to a significant improvement of survival. We summarize herein modern diagnostic and therapeutic management of CLL.
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