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Aluminium loading during therapeutic plasma exchange.

F Monteagudo, L Wood, P Jacobs

Journal of Clinical Apheresis

|January 1, 1987

Summary

Therapeutic plasmapheresis patients showed increased plasma aluminium levels due to albumin contamination in replacement fluids. Monitoring albumin aluminium content is crucial to prevent aluminium overload and associated health risks.

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Area of Science:

Clinical Chemistry
Toxicology

Background:

Therapeutic plasmapheresis is a medical procedure involving plasma exchange.
Patients with renal impairment are susceptible to aluminium overload complications.

Purpose of the Study:

To investigate the cause of elevated plasma aluminium levels in patients undergoing plasmapheresis.
To assess the aluminium content in albumin-based replacement fluids.

Main Methods:

Graphite furnace atomic absorption spectroscopy was employed.
Plasma aluminium levels in patients were measured.
Aluminium concentration in albumin samples was quantified.

Main Results:

A fivefold increase in median plasma aluminium levels was observed in four patients.

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Albumin replacement fluids contained high aluminium levels (646-715 µg/L).

Contamination occurred during albumin preparation.

Conclusions:

Albumin contamination in replacement fluids is a source of aluminium loading during plasmapheresis.
Monitoring aluminium in albumin fluids is essential to prevent toxicity.
Aluminium overload can lead to encephalopathy and osteomalacia in renal patients.